Control of complement activation in membranous and membranoproliferative glomerulonephritis
نویسندگان
چکیده
منابع مشابه
Classical complement pathway activation in membranoproliferative glomerulonephritis.
Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...
متن کاملSjögren Syndrome-Related Membranous Glomerulonephritis Progressing to Membranoproliferative Glomerulonephritis
We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluoresc...
متن کاملAdvances in Membranous and Membranoproliferative glomerulonephritis: Insights into Pathogenesis
Membranous glomerulonephritis is characterised by accumulation of immune complexes on the outside of the glomerular basement membrane. This leads to development of projections of the membrane adjacent to the deposits which eventually become incorporated into the membrane. In about 20% of cases the disease occurs in association with another condition such as SLE, cancer or drug exposure. The rem...
متن کاملAnti-Complement Autoantibodies in Membranoproliferative Glomerulonephritis and Dense Deposit Disease
The complement system is an essential part of innate immunity by its role in protection against infections, but it is also involved in waste disposal and in modulating the adaptive immune response. Under physiological conditions complement activation is effectively regulated to restrain it to the required targets and extent, and to prevent collateral host tissue damage. An imbalance between com...
متن کاملHereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis.
Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive renal disease that is diagnosed on the basis of renal histological features. Several MPGN subtypes have been defined by the localization and composition of glomerular deposits (electron dense, Ig and C3). MPGN II or dense deposit disease (DDD) which is defined by the occurrence of electron dense deposits within the lamina ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1980
ISSN: 0085-2538
DOI: 10.1038/ki.1980.62